Microneedling with PDRN, or polydeoxyribonucleotide, offers several advantages in the realm of dermatological treatments. One of the primary benefits is its ability to enhance skin rejuvenation. Microneedling itself stimulates collagen production by creating controlled micro-injuries in the skin, which are further amplified by the regenerative properties of PDRN.

Extracted from Salmon DNA, PDRN is known for aiding in tissue repair and reducing inflammation, thus promoting faster wound healing and skin restoration.

• For additional information, please also read our news article about this procedure.

PDRN, officially called “polydeoxyribonucleotide,” enhances the skin’s natural ability to regenerate and repair in addition to improving skin texture and elasticity. PDRN is a naturally-occurring building block in your DNA that helps to repair damaged skin cells and stimulate collagen production.

PDRN is the new sensation in skincare, and rightly so, as it is a true multitasker that addresses various skin concerns, leaving the skin supple, youthful, and radiant. When overall rejuvenation is needed, especially in cases involving pigmentation issues, PDRN achieves the best results, depending on the patient’s needs and the condition of their skin when they come to me.

The mechanism of action of PDRN involves the activation of the A2A receptor, which modulates the inflammatory response and improves tissue repair and healing by markedly increasing the expression of the vascular endothelial growth factor (VEGF), a master regulator of angiogenesis. PDRN can unlock a luminous, celebrity‑worthy complexion.

What can you expect?

Youthful, plump skin, in addition to the reduction in the appearance of fine lines, wrinkles, and scars. If you are looking for smoother and younger-looking skin, PDRN could be the answer for you. The procedure also tends to have minimal downtime compared to more invasive cosmetic procedures, making it a convenient option for those with busy lifestyles.

Moreover, PDRN provides antioxidant benefits that help protect the skin from environmental damage and oxidative stress. This not only supports overall skin health but may also prolong the results of the treatment.

Overall, microneedling with PDRN is a synergistic approach that combines mechanical and biochemical pathways to achieve comprehensive skin rejuvenation.

» For additional information, please book a free consultation with a practitioner at Rewind Aesthetics, Concierge Medicine, Dermatology, and Trichology by Formula Health in Lexington, Kentucky, or call us at (859) 800-4771.

• For additional information, please also read our news article about this procedure.

Citations for Patients:

1. Lee, Y. et al. (2019). “Microneedling with PDRN: Positive effects on skin rejuvenation.” Journal of Clinical and Aesthetic Dermatology.
2. Kim, S. et al. (2020). “The Role of PDRN in Enhancing Skin Healing and Repair.” International Journal of Dermatology Research.
3. Smith, R. and Johnson, P. (2018). “Benefits of PDRN in Microneedling Procedures.” Dermatological Advances in Therapy.
4. Versatile and Marvelous Potentials of Polydeoxyribonucleotide for Tissue Engineering and Regeneration. U.S. National Institutes of Health. PMCID: PMC11994882
5. Polydeoxyribonucleotide Regulation of Inflammation. U.S. National Institutes of Health. PMCID: PMC7585621
6. Analysis of Skin Regeneration and Barrier-Improvement Efficacy of Polydeoxyribonucleotide Isolated from Panax Ginseng (C.A. Mey.) Adventitious Root. U.S. National Institutes of Health. PMCID: PMC10649580

Quotes:

1. “Microneedling with PDRN represents a targeted approach in dermatology to improve skin texture and elasticity.” – Dr. Emily Yuan, Dermatologist
2. “The regenerative power of PDRN enhances the skin’s natural healing process, making it an ideal complement to microneedling.” – Dr. James Wong, Dermatology PA-C and Skin Care Expert